Our Health Care Team:
In addition to physicians who are Board certified in cardiology, internal medicine or another relevant specialty, MD Revolution’s health professionals include nutritionists, a metabolic specialist, physical fitness experts, and yoga therapists, all of whom have track records of success in guiding and motivating clients to maximize their health and wellness.
MD Revolution’s DNA-Complete, DNA-Select and DNA-Fit are the only “personalized health” programs headed by a physician with Board certifications in both cardiology and internal medicine and with expertise in personalized medicine, genomic medicine and mobile health (mHealth).
Our Unique Approach to Health Care:
MD Revolution merges state-of-the-art traditional medicine with cutting-edge, proven advances in the rapidly evolving fields of:
Personalized medicine is revolutionary because it replaces the current “shotgun,” or “one-size-fits-all” approaches to the diagnosis and treatment of disease, with an unprecedented, proactive form of health care tailored to your unique biology, medical and family history, and lifestyle.
Genomics pioneer, physician and biotech entrepreneur Leroy Hood, M.D., Ph.D., recently described personalized medicine as P4™ medicine based upon the following four tenets:
- Personalized, taking into account an individual’s genetic profile;
- Preventive, focusing on wellness, not disease;
- Predictive, anticipating health problems and drug reactions; and
- Participatory, empowering patients to take more responsibility for healthcare decisions.
DNA-Complete and DNA-Select are both P4 health care platforms that harness both genomic and mobile health technologies.
Links
- “The new science of personalized medicine,” PricewaterhouseCoopers. 2009.
- “Personalized Medicine Fact Sheet,” National Institute of General Medical Sciences of National Institutes of Health (NIH).
- “Personalized Medicine: How the Human Genome Era Will Usher in a Health Care Revolution,” National Human Genome Research Institute of NIH.
- “Personalized Medicine,” Technology Review.
- “The Decision Tree: How Smarter Choices Lead to Better Health,” Wired. 2010.
- “The Experimental Man Project” website.
Virtually every human ailment, except trauma, has some basis in our genes, which are units of DNA that carry the instructions for the cells in the body to manufacture specific proteins or sets of proteins.
By studying the entire human DNA code, or genome, scientists have identified genetic variations that increase risk for developing specific diseases. Many individuals, including Francis Collins, M.D., Director of the National Institutes of Heath, have had their DNA tested to determine their own genetic predispositions to diseases.
“It did affect me to find out that I was at risk for diabetes, which I had no family history of. But my family has all been extremely lean and I was not so lean, as I discovered when I got this information,” said Dr. Collins, author of the book, The Language of Life: DNA and the Revolution in Personalized Medicine.
In an interview with Kaiser Health News, Dr. Collins described his genetic testing as a “wake-up call” to change his diet and to exercise – and thereby lose 25 pounds.
Similarly, DNA-Complete and DNA-Select may provide a “wake-up” call for you.
DNA-Complete is the first personalized health program to use whole genome sequencing (WGS) to decipher a patient’s DNA code. The DNA that is analyzed by WGS comes from a single blood collection or saliva sample. To guarantee your privacy, your physician will use a code, not your name, to identify the saliva sample and the WGS report.
WGS differs from the commercial DNA tests that are now available to consumers. The human genetic code (DNA) has six billion base pairs (each base pair can be compared to one word in a book). While commercially available DNA tests analyze a small fraction of these base pairs (typically about 200,000 base pairs), WGS unravels and documents the entire genome.
Thus, DNA-Complete will “read” and “store” the whole book of your DNA. The advantage of adding WGS to medical care is that once your whole genome is sequenced, it can easily be re-examined for medically relevant variations as new scientific discoveries emerge.
Until now, the cost and the complexity of interpreting WGS data have limited its use in patient care. However, the development of advanced bioinformatics technologies using supercomputing, in collaboration with locally trained experts in genomic medicine, will allow MD Revolution to provide the most detailed insight into your genetic code available in the world today. This state-of-the-art, clinically relevant analysis will allow DNA-Complete to identify your risks for developing specific diseases, such as diabetes, as well as the likelihood that you will respond positively, or negatively, to certain medications.
The WGS analysis will serve as the core of DNA-Complete’s comprehensive and wide-reaching series of health assessments Thus, your personalized DNA-Complete assessment will integrate the analysis of your WGS with the findings from your physical examination, medical and family history, lab tests, nutrigenomics scan, and mobile health monitoring of your blood pressure or other biometrics.
Links
- “A Guide to Your Genome,” National Human Genome Research Institute, 2007.
- “Medical and Societal Consequences of the Human Genome Project,” New England Journal of Medicine 1999 article by Francis Collins, M.D., Ph.D., then Director of the National Human Genome Research Institute.
- “Genetic Code of Human Life Is Cracked by Scientists,” New York Times. June 27, 2000
- “Biology 2.0. A decade after the human-genome project, writes Geoffrey Carr, biological science is poised on the edge of something wonderful,” The Economist. 2010
- “Marathon man. Genomics has not yet delivered the drugs, but it will,” The Economist. 2010.
- “The Genome Speaks,” article by Samir Damani, M.D., Pharm.D., F.A.C.C., Science Translational Medicine. 2010.
Mobile health technologies now enable the continuous real time monitoring of blood pressure, heart rate and rhythm, basal metabolic rate, blood glucose, and sleep patterns to name a few. Such data can then be used to fine-tune a behavioral, lifestyle, exercise, and medical regimen tailored to your biology and optimized for your long-term health and wellness.
On your first visit as a DNA-Complete or DNA-Select patient, the physician may prescribe mobile health real-time monitoring of these biometrics. Only those devices that the physician has personally tested and found to be reliable, comfortable and easy to operate will be recommended to you.
In DNA-Fit, patients will learn how to use mobile devices to monitor exercise activity and track relevant clinical metrics, including their basal metabolic rate.
One mobile health device that you may be asked to use is a blood pressure monitor that connects to your smartphone. With the device, you will be able to periodically measure and record your blood pressure over 1 to 2 weeks and wirelessly share your results with your DNA-Complete/DNA-Select physician.
Mobile health technologies can reveal novel information that could influence your eating habits, exercise routine, and the time and dosing of medications, as well as your health and wellness strategies. All this information is portable and can be transferred to your personal physician.
Links
- “Mobile Health: Wireless Technology a Key to Improving Care, Lowering Nation’s $2.5 Trillion in Medical Spending, Exec Says Healthier Practices: Mobile Health Wireless Technologies a Key To Improving Care,” San Diego Business Journal
- “Wireless Future of Medicine,” Eric J. Topol, M.D.’s presentation at TEDMED 2009.
- “Transforming Medicine via Digital Innovation,” Science Translational Medicine. 2010.
- “Medicine on the Move. Mobile Devices Help Improve Treatment,” Wall Street Journal. 2011
- “Enabling Personalized Medicine through Health Information Technology,” Center for Health Care Technology at Brookings, 2011.
- “A Physician’s Perspective on Self-tracking. How can we get the average patient to take charge of their health?” published by Technology Review. 2011.
- “A Dashboard for Your Body,” New York Times. 2011.
- “The Measured Life,” Technology Review. 2011.
- “Know Thyself: Tracking Every Facet of Life, from Sleep to Mood to Pain, 24/7/365,” Wired.
- “Wireless technologies are about to transform health care, and not a moment too soon,” IEEE Spectrum. 2011.
- “An App to Track Your Heart Pressure. Data from an implanted device can be shared with the patient, doctors, and family,” Technology Review. 2011.
- “Smart Phones Help Manage Chronic Illness.” Technology Review. 2011.
“The one-size-fits-all exercise programs are not effective or efficient for many people,” said Johanna Casler, MD Revolution’s Metabolic Specialist and a nationally-recognized fitness expert. “Even though they are spending a lot of time in workouts, they don’t achieve their fitness goals, whether they be weight loss or improved endurance, strength and flexibility.”
MD Revolution takes a personalized approach to health and fitness. Before prescribing an exercise regimen for a MD Revolution patient, Ms. Casler assesses the individual’s metabolic fitness through a series of non-invasive tests that determine the resting metabolic rate, or the amount of calories “burned” when the body is at rest, and the target heart rate zones that will achieve the desired caloric “burn” during workouts.
A carefully planned and executed exercise program will boost the individual’s resting metabolic rate, so that more calories are burned even during sleep.
Metabolic fitness, the most validated method for objectively determining overall fitness, is used by many professional athletes to optimize their performance. MD Revolution is unique in bringing the metabolic fitness assessment and many other cutting-edge health and wellness strategies to patients.
MD Revolution is able to customize a workout program with the exercise intensity that enables the individual to achieve his or her fitness goals in the least amount of time.
To conduct the metabolic fitness tests, Ms. Casler uses state-of-the-art, medical grade equipment designed for hospitals and medical clinics. MD Revolution is one of the few private medical practices with this equipment, which also is rarely found in fitness facilities.
Armed with the test results, Ms. Casler tailors a CardioZone program that will be effective and efficient for each MD Revolution patient.
“Our clients are busy people and don’t have time to waste on inefficient workouts,” said Ms. Casler. “My training philosophy is simply to design fitness programs and classes that allow clients to have the most effective, time efficient, safe and motivating workout possible.”
Ms. Casler tailors each CardioZone program according to her metabolic assessment of the patient. The test results help identify the heart rate training zones that will maximize the expenditure of calories and improve the patient’s fitness level.
By focusing on the appropriate training zone, the MD Revolution patient improves his or her ability to use oxygen, and thereby burn more calories, particularly from body fat.
Increasing the resting metabolic rate is critical not only to overall health and wellness but also to long-term weight management, since an individual’s metabolic rate typically slows as we age.
CardioZone differs from the workout programs that restrict caloric intake to lose weight. Such caloric restriction can decrease metabolism, therefore reducing the amount of calories that can be consumed to prevent weight gain.
“CardioZone shows you how to light your metabolic fire,” said Ms. Casler.
Because these three programs also focus on your daily health and wellness, your physician may recommend exercise training or nutrition counseling that will be tailored to you.
“These programs are our first real opportunity to implement health and wellness strategies that may actually prevent many Americans from needing surgical interventions, from cardiac bypass to kidney transplants to bariatric surgery,” said Sunil Bhoyrul, M.D., F.R.C.S., F.A.C.S., Co-Founder of MD Revolution, Inc.
“Shifting our emphasis from surgery to prevention, and also improving the outcomes of those who ultimately need surgery are imminently achievable goals. Let’s learn how to eat, sleep, exercise and work in a manner that is best suited to our individual make up,” added Dr. Bhoyrul, a world authority on minimally invasive and obesity surgery.